Posted by Caleb462 on June 11, 2003, at 22:07:41
In reply to More on EffexorXR dosing ... » cybercafe, posted by Janelle on June 11, 2003, at 18:01:58
Effexor, as a dopamine uptake inhibitor, is very weak... I highly doubt 225 mg has any noticeable effect on dopamine systems. 150 mg is usually the official dose given for signifigant NE uptake inhibition to begin, though I'm sure 75 mg has a weak effect. 225-300 mg is probably the range where Effexor acts most like an SNRI. This is just an assumption of course.
I'm curious as to what role dopamine plays in higher doses of Effexor... for example, some people take doses as high as 450 mg.. I wonder if there is any signifigant dopaminergic action going on at this point? My guess is not much... but who knows? There's been trials that have used as much as 600 mg of Effexor, I bet dopamine uptake inhibition does become a strong part of Effexor's action here... but having never experienced more than 225, I can't say.
poster:Caleb462
thread:232443
URL: http://www.dr-bob.org/babble/20030609/msgs/233326.html