Posted by samplemethod on June 7, 2003, at 23:13:53
In reply to Re: Enada NADH and 5-HTP » Barbara Cat, posted by Ron Hill on June 7, 2003, at 19:45:06
Hey Ron,
Are you still taking Niacin (nicotinic acid)...
studies have shown some interesting benzoish workings of niacinamide.....but whats up with the niacin functioning??
anyone have an idea?
> Hi Barbcat,
>
> > You're post reminded me to start taking NADH again. It really helped when I was having real bad fibromyalgia fatigue. Maybe you could answer questions I have about the sublingual 'action' NADH vs. the enteric coated swallowed. I know that the sublingual will get absorbed faster and it's a larger dose, probably targeted for mongo workouts, but do the two types affect you differently in general?
>
> The main diference I found between the sublingual ENADAlert NADH and the down-the-hatch enteric coated Enada NADH is that the later has a smoother more prolonged action. The action of the sublingual formulation seems to spike up quickly, reaches a higher peak, and then drops off more quickly than the enteric coated tablet. I took 10 mg/day of the sublingual formulation for the first ten days, but it then started to cause irritability. Therefore, I switched to the enteric coated tablets. In hindsight, I don’t think the irritability was due to the sublingual formulation per se because, as I found out later, the enteric coated tablets cause the same irritability if I take too much.
>
> > I have a bit of the sublingual type left and don't think I need 10mg of it, so I'd appreciate your input on dosing.
>
> Feel free to cut the sublingual tablets into smaller dose sizes. Obviously, cutting the enteric coated tablets will render the tablet useless because the stomach acid with destroy the NADH contained within the breached enteric coating and, therefore, the NADH will not make it to the intestines where it can be absorbed. Such is not the case, of course, with the sublingual formulation.
>
> As far as dosing, I found that 10 mg/day of the sublingual formulation was a good dose during the acute treatment phase (lasting about ten days) of my bipolar atypical depression. Your dose requirements for your fibromyalgia fatigue may differ from my experience. As a maintenance dose, I take a 2.5 mg enteric coated tablet once or twice a week depending on how I feel. The addition of 250 mg/day of TMG and 250 mg/day of niacin are very important in order to abate my bipolar related irritability, and the added irritability caused by Enada NADH.
>
> > One other thing, you mentioned 5-HTP. I had no effect at all on it and in fact it made me feel more depressed, but I had very good results with l-tryptophan. Something to do with tryptophan hits a few more sites along the way before it's converted to 5-HTP. It helped mostly with the fibromyalgia muscle aches, so there's something in those first few steps that I was needing that 5-HTP wasn't doing.
>
> Prior to johnj telling me about the efficacy of niacinamide (and niacin) for treating irritability, I was using about 25 mg/day of 5-HTP, spread out throughout the day on an as-needed basis, to help control my irritability. It helped a little for maybe an hour or so after taking a micro-dose, but it was not a profound benefit. I had the feeling that even the small amount of benefit would fade if I were to increase the dose size or frequency. But that was just my spectulation.
>
> > Always nice to chat with you.
>
> And with you, Oregon Barbcat!
>
> -- Ron
>
>
>
poster:samplemethod
thread:230335
URL: http://www.dr-bob.org/babble/20030604/msgs/232299.html