Posted by MB on May 29, 2003, at 21:08:46
In reply to Re: HPA, Atypicals and Opiates?--Cam?? » MB, posted by jrbecker on May 29, 2003, at 16:13:19
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> Some experts believe that a potentiator of CRH might be beneficial for atypical depressives, while others disagree.
I think I read somewhere that naltrexone might help in this area...stimulating the hypothalamus to release CRF...
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> I remain sleepy throughout the day and have a lot more rebound energy at night. I've even found that if I push my sleep cycle further into the night and wake up later in the day, that I have a much a more normal circadian clock.I've noticed the same thing. After a night's sleep, I still feel groggy (I also suffer from Restless Leg Syndrome) and my morning .5mg Klonopin dose knocks me on my butt. However, I start to feel rejuvinated as the sun goes down, and I hardly feel my evening 1mg dose of Klonopin at all. Also I've been noticing that my moods cycle in a way opposed to what you would see in someone with Seasonal Affective Disorder: I'm more sluggish, tired, and depressed in the Summer than in the Winter. In the Spring and Summer, I actually *loathe* to go out in the sun, and usually wait until dusk to go outside, to do my shopping, etc. (or if I get up before dawn, and rev up on coffee--which activates the stress system--I can function somewhat normally).
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> This is probably due not only due to its 5HT1A action but also because one of its metabolites is an alpha-2 adrenergic antagonist (which increases NE and dopamine).
Would this make it like a BuSpar/Remeron hybrid in terms of action?
<cut>> On another note, have you experimented with supplements -- SAMe, Folate, Fish oil, DHEA, NADH. What about light therapy (it's actually helped my energy levels). And what about CBT? Given it any thought? There's lots of proof that atypical depression responds to it.
I've experimented very little with the above supplements. SAMe made me restless and irritible (much in the way SSRIs do, hence the Klonopin ingredient in my cocktail). I'd really like to try CBT.
Thanks for the hopeful/informative input and the links...
MB
poster:MB
thread:228381
URL: http://www.dr-bob.org/babble/20030525/msgs/230080.html