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Re: Ace,Need some help....really appreciate an answer!

Posted by Caleb462 on May 28, 2003, at 0:41:59

In reply to Ace,Need some help....really appreciate an answer!, posted by McPac on May 27, 2003, at 23:01:26

> Ace, GREAT to hear that your Nardil is working so well for you!
> I've been searching the 'net and it looks like Remeron indirectly acts as a partial agonist at the 5HT1a receptor site. So that should be pretty good for me (that should lessen anxiety). The ssri's have the opposite effect at that site; by raising serotonin at all sites, they increase or further activate that site (making some people feel worse anxiety/anger). I'm so glad that the Nardil is working so good for you Ace---if I were you I'd stay on it for life! I did briefly take Nardil many years ago and it worked VERY GOOD for me too....but I was always so afraid of eating anything...I was afraid I'd eat something that would cause problems....I remember my doctor at the time saying to even watch out for meat tenderizers...it made me afraid to eat burgers or meats....I eat out a lot and was always worried that I'd eat something that would make me have a bad reaction...got to go...need some sleep! Take care Ace!

From my understanding... Remeron, by antagonizing alpha-2 receptors, increases serotonin release. And since Remeron blocks both 5-HT2 and 5-HT3 receptors, much of that serotonin gets directed to the 5-HT1a site. So, yeah, an indirect agonist of sorts.

The serotonin receptors are mighty confusing - particularly since some forms (like 5-HT1a, I THINK), appear both pre-synaptically and post-synaptically, and can have different actions depending on this (again, I THINK). I think the 5-HT2c receptor is really the only receptor I have a definite grasp on.

I love pharmacology, and am probably going to go into the field as my career - but I'm only beginning to understand it, can be very complex stuff.


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