Posted by CamW. on May 24, 2003, at 15:43:02
In reply to famotidine, omeprazole etc., posted by Kari on May 23, 2003, at 15:20:25
I researched the use of famotidine (Pepcid™) in pschosis and schizophrenia a few years ago after I stumbled across an article in an older (mid-70's?) European psychiatry textbook that mentioned it in passing. High doses of famotidine supposedly relieved psychosis and helped to prevent recurrances in at least one case of schizophrenia. What I found was one paper (non-controlled) that tried using it in a few treatment-resistant cases.
I have the article, but my all my psychopharmacological files are boxed and stored). I believe that I found the article cited in a British Journal of Psychiatry. Forgive me, my memory ain't what it used to be.
In any case, the results in the article were not very convincing. Other mentions of using famotidine as an antipsychotic were in letters to the editor in a couple of journals.
Being unable to think of a rational mechanism of action, I discussed the paper with one of our more "open" researchers and he did try it for a short time in one patient without seeing any changes. It was one of those situations in which the patient's condition was even resistant to high dose clozapine (Clozaril™) and several multi-drug combinations, not a typical case.
I suspect that the remission of the psychosis in the initial instance was coinsidental (ie. natural remission).
FWIW - Cam
poster:CamW.
thread:228647
URL: http://www.dr-bob.org/babble/20030520/msgs/228897.html