Posted by jrbecker on May 22, 2003, at 16:44:50
In reply to You CANNOT lower CORTISOL directly, posted by davpet on May 22, 2003, at 15:44:57
thus, the continuing CRF antagonism research. Organon is taking another approach to this, it's clinical trial drug ORG 34517 (a glucocorticoid receptor antagonist) also works by reducing cortisol. ORG 34517 was found to be comparable to paroxetine in a double-blinded, paroxetine controlled trial with 142 patients. Nemifitide is a drug in the class of novel brain peptides (synthetic) currently in Phase II (efficacy) and III (large scale) clinical trials. The company manufacturing nemifitide (Innapharma) claims this class of drugs offer benefits over SSRI agents, including rapid onset of action and better side effect profile. How this class of drugs act is still under investigation.
JB
poster:jrbecker
thread:228381
URL: http://www.dr-bob.org/babble/20030520/msgs/228399.html