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Selegiline and methylphenidate

Posted by Rubena on May 17, 2003, at 1:35:38

I've been taking selegiline (an MAOI), 25 mg, for 12 years, and methylphenidate-SR, 40 mg bid, for 4 years. About two years ago I found myself unable to get back into condition after several weeks interruption of my lifelong jogging habit. The "deconditioning" has persisted, with main problem a rapid heart rate with minimal exercise. Resting heart rate is still 60 or below, and blood pressure is low (not too low). Pulmonary workup: A-OK. Cardio workup: EKG and echo basically normal, heart structurally normal, good strong contractions with exercise. . . but tachycardia most of the time except first thing in morning before getting up. I now get winded climbing single flight of stairs. Cardiologist suggests meds are the culprit. The methylphenidate I can reduce or eliminate, but numerous attempts to taper selegiline (e.g., - 2.5 mg every fourth day) have always brought on immobilization that prompted antidepressant use originally. Is it plausible that the medication(s) are the source of the problem? I always thought that hypertension was the side effect to watch out for, and that has not occurred. Thanks.


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poster:Rubena thread:227174
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