Posted by Questionmark on May 14, 2003, at 1:23:14
In reply to Re: Anafranil begun! The good and bad.... » ace, posted by freedom2001 on May 12, 2003, at 23:19:13
>"why does the OCD has to get worse to become a good indicator for excellent responses??????"
i think it's because of the stimulation of 5-HT (serotonin) autoreceptors that occurs early on (bcz of that extra serotonin floating around from the reuptake inhibition), which results in decreased 5-HT release. Eventually (within about a month) the autoreceptors downregulate and there is an increase in 5-HT release. . That's how i understand it anyway; i could be wrong.
i guess we're lucky that the autoreceptors apparently downregulate so much faster than the postsynaptic receptors-- otherwise SRIs wouldn't work, right? Weird.
poster:Questionmark
thread:225964
URL: http://www.dr-bob.org/babble/20030505/msgs/226498.html