Posted by Larry Hoover on May 12, 2003, at 11:03:20
In reply to Mac Pac, Ame Sans Vie, does this mean it's good?, posted by lawrence S. on May 12, 2003, at 0:43:55
> Well, I picked up some Niacinamide 100mg at GNC for $5.00 How often should I take it? It is in tablet form and is not time released.
You could probably use it prn, "as needed", without any concern for toxicity. Still, I wouldn't exceed 500 mg at a dose, nor 2000 mg/day. I'd try to stay under those levels, most of the time.
> 15 minutes after taking the first tablet I noticed a signifcant feeling of calm. Is this placebo effect or could it actually work this fast?
It most certainly could work that fast. Whether it was placebo or not is a difficult question for anyone but you to answer. Repeated trials should clear up that mystery for you.
> Acetylcholine potetiation, I thought caused increased anxiety?Perhaps, the opposite is true.
Brain Res 2002 Sep 13;949(1-2):60-70
Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests.Degroot A, Treit D.
Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9.
There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampus in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. We found that microinfusions (10 microg/0.5 microl) of the acetylcholinesterase inhibitor physostigmine in either the dorsal or the ventral hippocampus increased rats' open arm exploration in the plus-maze test, and decreased burying behavior in the shock-probe test. Interestingly, infusions in the ventral, but not the dorsal hippocampus also increased the number of contacts rats made with the shock-probe. Overall, the results suggest that cholinergic stimulation in the dorsal and ventral hippocampus modulate anxiety, but that only the ventral hippocampal cholinergic system is involved in the passive avoidance of painful stimuli.
poster:Larry Hoover
thread:225568
URL: http://www.dr-bob.org/babble/20030505/msgs/226084.html