Posted by JrBecker on May 5, 2003, at 17:17:07
http://pn.psychiatryonline.org/cgi/content/full/38/9/1-a
Binding Detected In Untreated Depression
A DGReview of :"5-HT 2A receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study"
Psychopharmacology05/02/2003
By James Adams
Patients with major depressive disorder who have never been treated with antidepressants, have reduced 5-HT2A receptor binding compared with drug-treated euthymic patients and healthy controls.Investigators from the University of Milan in Italy, and the Instituto de Investigaciones Biomedicas de Barcelona in Spain, studied 19 drug-naïve patients with major depressive disorder, 15 paroxetine-treated euthymic patients and 20 healthy controls.
Positron emission tomography (PET) with [18F] fluoroethylspiperone, a 5-HT2A and D2 receptor antagonist was performed on all subjects. Binding index was calculated as the ratio of activity in the cortical and basal ganglia to activity in the cerebellum. Binding index was compared among the three groups of study subjects.
Results showed that binding index was significantly reduced in the frontal, occipital, temporal and cingulated cortices in drug-naïve patients compared with the other two groups. Binding index was not significantly different between the drug-treated euthymic patients and controls.
Reduced [18F] fluoroethylspiperone binding index in the cortical areas of drug naïve depressed patients and not in drug-treated euthymic patients suggests that depressive symptoms may be associated with impaired cortical 5-HT2A receptors, according to the investigators.
It is possible that [18F] fluoroethylspiperone binding index is a state marker of depression, the investigators suggest.
Psychopharmacology 2003;167:72-78. "5-HT 2A receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study"
poster:JrBecker
thread:224544
URL: http://www.dr-bob.org/babble/20030505/msgs/224544.html