Posted by JrBecker on May 2, 2003, at 14:45:37
In reply to JB, Re: Remeron and sexual s/e, posted by McPac on May 1, 2003, at 20:35:28
McPac-
NO does have a minor role in SSRI-induced sexual dysfunction, but the main cause is that they agonize the 5ht2 receptor plate (this also has an effect on lowering prefontal dopamine and furthers sexual dysfunction). Another smaller role is the 5HT3 receptor. Consequently, this is why mirtazapine works so well as an adjunct to combat an accompanying SSRI therapy or as a sexual performance drug on its own. See link for more of an explaination...
http://www.biopsychiatry.com/ssrisex.htm
By the way, just for reference, the two prominent receptors involved in ejaculation are the 5HT1A and D2 receptors.
> Thank you very much!!
>
> 5HT2...."which is of course the major culprit with SSRI-induced sexual dys"
>
> >>>>What do the SSRI's DO at this 5HT2 site that causes the sex/dysf.?
>
> (I read that nitric oxide was the factor in ssri-induced sex. dysf.....???)THNX!
poster:JrBecker
thread:223540
URL: http://www.dr-bob.org/babble/20030429/msgs/223865.html