Posted by Caleb462 on May 2, 2003, at 2:48:22
In reply to Can Anybody help answer this question?, posted by McPac on May 1, 2003, at 18:47:04
"In major depression, an increase in 5-HT1A transmission is thought to be a crucial determinant of the antidepressant response"
http://collection.nlc-bnc.ca/100/201/300/cdn_medical_association/jpn/vol-26/issue-1/0037.htm
However... I also found several sources that mentioned 5-HT2 downregulation as being important in anti-depressant response, continued use of a 5-HT2 antagonist would likely result in 5-HT2 upregulation - though I guess initially 5-HT2 antagonism would mimic 5-HT2 downregulation. I dunno.... depression and anti-depressants just aren't well understood - lots of contradictions and confusion. Remeron works by itself though, and I would think combining it with Zoloft would only help it's action as anti-depressant.
poster:Caleb462
thread:223705
URL: http://www.dr-bob.org/babble/20030429/msgs/223789.html