Posted by action_jackson on April 16, 2003, at 23:38:05
In reply to Re: 4 days on amisulpride - great for SP? , posted by Michael Bell on April 16, 2003, at 19:26:29
Hi Michael -
I work in an ER and I see quite a bit of acute dystonic reactions from Reglan. This is a an FDA approved substitute benzamide used for nausea - the same class of med Chad says amisulpride is in...
I suggest to look up metaclopramide on google and see if you find any data on that - there is no question that Reglan can cause severe EPS. If you look up PDR data on Risperdal you will see that the newer atypical a/p's not uncommonly cause severe EPS reactions as well ... I personally believe we see more EPS in the ER from Reglan only because it is more often given to "normals" in acute or sub-acute use.
Jack
> Chad, sorry if I came on too strong in the last post. The point I should have made was that all the research studies I have read say that low dose amisulpride is very safe. Dosage is very important when considering side effects. The average dose of amisulpride for schizophrenics is between 400 - 800 mg per day. Also, it's important to note that this drug has opposite effects at low and high doses. At low doses (0 - 200mg/ day), it selectively blocks PREsynaptic dopamine receptors, thus increasing dopamine transmission. This seems to be the reason why it has proven helpful for negative symptoms of schizophrenia and dysthymia. At higher doses (400 - 800mg/ day) it blocks POSTsynaptic dopamine receptors, and is helpful for curtainling the positive symptoms of schizophrenia. So I agree that taking doses in the high range may pose some of the same TD problems as the older TDs, but the dose I'm taking is only 1/16th of the lowest doses for schizophrenia. I've yet to come across a study that shows type of dosage to be unsafe.
>
> And for anybody else out there... does the drowsiness go away after a while? Did the positive effects of this drug last? Thanks!
poster:action_jackson
thread:219673
URL: http://www.dr-bob.org/babble/20030411/msgs/219943.html