Posted by Shawn. T. on March 13, 2003, at 16:19:44
In reply to Re: Remeron, question about high dosages, posted by Caleb462 on March 13, 2003, at 3:34:59
Remeron doesn't inhibit norepinephrine reuptake at high doses; its activity as a norepinephrine alpha-2 receptor antagonist increases. Alpha-2 receptors act as norepinephrine autoreceptors; that means that when certain alpha-2 receptors are activated, they decrease the release of norepinephrine. Remeron blocks these receptors, and it increases extracellular norepinephrine to greater degrees as the dosage taken increases. The increased extracellular norepinephrine activates beta2/beta3-adrenoceptors; this is the same mechanism through which caffeine indirectly causes weight loss.
Shawn
poster:Shawn. T.
thread:208638
URL: http://www.dr-bob.org/babble/20030310/msgs/208804.html