Posted by Ritch on March 11, 2003, at 23:24:08
In reply to Prozac/BuSpar combo: good or bad?, posted by yeltom on March 11, 2003, at 20:33:15
> I've been on trazodone, buspar, and celexa for a while. The celexa seemed to lose its effectiveness, so my doctor switched me to prozac. I've read conflicting reports about the prozac/buspar combo. I've read (1)that prozac decreases buspar's effectiveness, (2)that the two drugs decrease each other's effectiveness, and 3(3)that buspar is a great way to augment prozac's effectiveness. Although (1) and (3) aren't strictly contradictory, I'm definitely confused. Would like to hear both from people who've tried the combination and pharmocologically inclined people who can explain what actually happens when the two drugs are combined. Thank you.
Generally, the Buspar will dampen the serotonergic effect of the Prozac (and other SSRI's), and tend to boost noradrenergic and dopaminergic effects than Prozac alone. So, if you respond well to SSRI's by themselves, and respond poorly to TCA's/Wellbutrin/stims (i.e.), the Buspar add could possibly worsen your depression. If SSRI's tend to trigger a lot of apathy and anhedonia (although helpful for other symptoms) the add could prove beneficial. You will just need to try it and see what happens.
poster:Ritch
thread:208223
URL: http://www.dr-bob.org/babble/20030310/msgs/208279.html