Posted by jay on March 10, 2003, at 10:16:44
In reply to Psychiatric Drugs Chart - now includes half-life, posted by SLS on March 9, 2003, at 10:52:06
Hey Scott:Awesome job, info that EVERY psychiatrist should know. (Which many don't it seems!) I of course don't have much pharmacological knowledge, but just some questions about the SRI's.
I was wondering about various effects beyond serotonin of some of the SRI's. I noticed you have with Prozac (fluoxetine) and Zoloft (sertraline), but was curious about Celexa (citalopram), Paxil (paroxetine) and Luvox (fluoxetine). Maybe these others aren't really significant. I think that both Paxil and Celexa may have norepinephrine reuptake properties, as well as anticholinergic properties. I also am sure that Luvox has pro-melatonin properties. I've picked one abstract on each, but there are a large number of others from a Medline search. Please let me know what you think, and honestly I am not trying to stir up *anything*..ok? :-):
Here is one of many on Paxil..and I hope I have this right:
Am J Psychiatry 2002 Oct;159(10):1702-10
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine.One that implicates anticholinergic properties of Celexa:
Psychopharmacology (Berl) 2001 Apr;154(4):343-9
The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.And one on melatonin and Luvox:
J Clin Psychopharmacol 2001 Apr;21(2):167-74
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.Thanks again...
Jay
poster:jay
thread:207392
URL: http://www.dr-bob.org/babble/20030310/msgs/207707.html