Posted by Michael Bell on March 2, 2003, at 13:19:58
In reply to Re: Picamilon for Social Phobia - GHB analogue?, posted by Kari on March 2, 2003, at 13:07:36
> What effect does GABA have on dopamine?
> Thanks.
GABA's main effect on dopamine is to inhibit its release, especially in situations where dopamine really shouldn't be released. It works like the brakes on a car. In the normal brain, when dopamine transmission has reached optimum rate, GABA is taken up by remaining dopamine cells, and this tells the cells to stop releasing dopamine. Then the enzyme for resonsible breaking down GABA destroys the GABA. When there is a dysfunction of GABA, there is uncontrolled release of dopamine (and norepinephrine) in situations that shouldn't trigger this reaction. So poor GABA function is like having brakes that don't work properly, so the car is out of control so to speak. GABA is also responsible for mediation of other transmitters, including serotonin and norepinephrine.
poster:Michael Bell
thread:205031
URL: http://www.dr-bob.org/babble/20030301/msgs/205296.html