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Re: Abilify produces sedation at low dosages only?

Posted by Thomas123 on February 23, 2003, at 21:00:55

In reply to Abilify produces sedation at low dosages only?, posted by SLS on February 23, 2003, at 20:12:42

There are a few holes in your theory. First of all presynaptic dopamine receptors when agonized reduce the release of dopamine. Presyaptic receptors are a feedback regulating mechanism. The idea is if there is a lot of dopamine in the synaptic cleft the dopamine will agonize a presynaptic receptor reducing the release of dopamine thereby lowering the amount of dopamine in the synaptic cleft.

Two, it is just false that one gets the same side-effects from high dosages as from low dosages. Dosages which block more than 65% of dopamine D2 receptors result in EPS. One gets more than 70% of those D2 recptors blocked and it is apathy city.

How I understand Abilfiy is it is a weak dopamine agonist. It binds strongly to dopamine D2 receptors blocking access by dopamine to the receptor but gives less of a charge than dopamine thereby toning down dopaminergic output.


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poster:Thomas123 thread:203168
URL: http://www.dr-bob.org/babble/20030219/msgs/203181.html