Posted by utopizen on February 16, 2003, at 9:43:09
Substituted azole derivatives as inhibitors of corticotropin releasing factor (Assignee -- Bristol-Myers Squibb Company)
Abstract: The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor and ..
U.S. Patents via NewsEdge Corporation : Abstract: The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor ("CRF receptor") and useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.Ex Claim Text: A compound of Formula (I) or a pharmaceutically acceptable salt or solvate thereof ##STR89## wherein X is O, S, NH or N--C.sub.1-6 alkyl; W and W' are each H; Z and Z' are independently CH or N provided that if Z' is N, then Z is CH; if Z is N, then Z' is CH; R.sup.1 and R.sup.2 are each the same or different and selected from the group consisting of H, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl, C.sub.1-6 alkyl-C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl, C.sub.3-6 alkynyl, C.sub.1-6 cyanoalkyl, C.sub.1-6 aralkyl, 5 or 6-membered heterocycle and 9 or 10-membered bicyclic fused heterocycle; wherein said C.sub.1-6 aralkyl is optionally substituted with one or more of the same or different halogens or with one or more of the same or different C.sub.1-4 alkoxy groups; said 5 or 6-membered heterocycle contains one to three of the same or different heteroatoms selected from the group consisting of O, N and S and said 5 or 6-membered heterocycle is optionally substituted with C.sub.1-4 alkyl, C.sub.1-4 thioalkyl, C.sub.1-4 haloalkyl, halo, cyano or --O--C.sub.1-4 alkyl; provided that if three of said heteroatoms are contained in said 5-membered heterocycle, said three heteroatoms are not all the same heteroatoms; said 9 or 10-membered bicyclic fused heterocycle contains one to three of the same or different heteroatoms selected from the group consisting of O, N and S; R.sup.1 and R.sup.2 together with the nitrogen to which they are attached form a five or six-membered heterocycle, said heterocycle containing one to three of the same or - different heteroatoms selected from the group consisting of N, S or O; and said heterocycle optionally substituted with one or more C.sub.1-6 alkyl, --C.sub.1-6 alkyl-C.sub.1-6 alkoxy or C.sub.1-6 alkoxy groups; R.sup.3 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, halo, cyano or C.sub.1-6 alkoxy; R.sup.4 is H or C.sub.1-6 alkyl; R.sup.5 is H, C.sub.1-6 alkyl or halo; R.sup.6 is C.sub.1-6 alkyl or halo; and R.sup.7 is H, C.sub.1-6 alkyl or halo; provided that if R.sup.5 is H, then R.sup.7 is not H; and if R.sup.7 is H, then R.sup.5 is not H.
Patent Number: 6515005
Issue Date: 2003 02 04
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Inventor(s): Dubowchik, Gene M.
Zuev, Dmitry S.
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