Posted by not exactly on February 13, 2003, at 23:51:43
In reply to Current Selegiline options: oral or sublingual? , posted by hok on February 13, 2003, at 20:33:02
The advantages of the transdermal delivery method are 1) negligible impact on MAO-A in the digestive system (freedom from "cheese effect"), 2) no first-pass gut metabolism (which produces active metabolites responsible for some of the side effects), 3) greater bioavailability (higher plasma concentration for the same amount), and 4) gradual continuous administration. I would think that the sublingual form would be almost as good as transdermal with respect to the first three advantages (the fourth advantage can be approximated with multiple divided doses). Oral is the least desirable route for high-dose (AD levels) selegiline (although obviously the most convenient).
- Bob
poster:not exactly
thread:140745
URL: http://www.dr-bob.org/babble/20030208/msgs/200273.html