Posted by SLS on February 12, 2003, at 23:29:23
In reply to Re: what is the best antipsychotic for depression?, posted by cybercafe on February 12, 2003, at 20:23:40
It is not such a new idea that neuroleptic antipsychotics can produce antidepressant effects in some people - even the older ones like Stelazine and Moban. For me, Risperdal, Zyprexa, and Geodon all demonstrated mild to moderate (although transient) antidepressant properties. As such, I found myself having increased mental energy, even during the periods of sedation and somnolence that occurred early in treatment. By the end of the first week, I was without these two side-effects, and just enjoyed the energizing effect that the improvement in depression afforded me. So, I guess I would avoid generalizing neuroleptic antipsychotics as sedating and depressogenic.
Yes, Geodon can be activating. It can also produce insomnia. However, neither of these are necessarily indicators of antidepressant effect.
Some people have used S-AMe successfully as a "bridge" between antidepressants or stimulants. I think it's worth a shot at relieving you of stimulant-withdrawal rebound-depression. This idea is probably whacked-out, but I wonder if amantadine (Symmetrel) might not mitigate the depression. Although it might not affect dopaminergic neurons directly, it does increase dopaminergic activity in certain areas of the brain secondary to its inhibition of NMDA receptors. Just a thought...
Let us know what you come up with!
- Scott
poster:SLS
thread:140762
URL: http://www.dr-bob.org/babble/20030208/msgs/140808.html