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Re: 5HT 2 antagonism?

Posted by Ritch on February 6, 2003, at 22:40:47

In reply to 5HT 2 antagonism?, posted by zeugma on February 6, 2003, at 10:18:43

> I'm curious about the effects of 5HT 2 antagonism. According to SLS' drug info sheet, nortriptyline causes 5HT2 antagonism but I have been having trouble finding out what possible effects this could have. Is it responsible for nortriptyline's beneficial effects on the gastrointestinal system? Before I started taking it I was very prone to nausea and severe GI pain, but it is much diminished. The last day I missed work due to nausea was the day I started taking nortrip. So something in that chemical is steadying my GI tract. Thanks in advance,
>
> z

Amitriptyline (nortriptyline's parent drug), is frequently used for IBS. I am not sure if it is the single most effective agent for it or not, but it is close. The anticholinergic effects of TCA's are usually attributed to why they work so well to "settle" GI symptoms.

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poster:Ritch thread:139789
URL: http://www.dr-bob.org/babble/20030204/msgs/139888.html