Posted by Caleb462 on January 29, 2003, at 23:44:17
In reply to Re: question regarding neurotransmitters PS » Caleb462, posted by noa on January 29, 2003, at 19:46:40
From the reading of done, 5-HT2c (and 5-HT2b, for that matter) activation results in inhibition of dopamine release in the mesolimbic and nigrostriatal dopamine systems. So yes, definitely this inhibition can have an effect an prefrontal cortex functions, motivation, initiative, reward, etc. Indeed, excess 5-HT2c activation could be a large cause of SSRI-induced apathy, anhedonia, fatigue, sexual dysfunction (though I believe that has a lot to do with 5-HT2a also), etc.
poster:Caleb462
thread:138127
URL: http://www.dr-bob.org/babble/20030125/msgs/138268.html