Posted by River1924 on January 25, 2003, at 21:18:18
In reply to Re: Abilify (sebastian), posted by 1313 on January 25, 2003, at 18:48:16
Found this on the web...
"Potential Problem with Akathisia
According to Larry Ereshefsky, Pharm.D., professor of pharmacy, pharmacology and psychiatry at the University of Texas Health Science Center at San Antonio, the novel partial dopamine agonist mechanism of action augments the 5-HT1a and 5-HT2 effects of aripiprazole."These effects should lead to greater dopaminergic throughput and cortical activity which is good for thinking," says Ereshefsky. "But it also might possibly explain the increased rates of akathisia at [the] middle doses (15 mg/d) in some studies. There is clearly a greater effect on the Barnes akathisia scale than [from] risperidone, and about half the effect of haloperidol."
Ereshefsy adds, "Akathisia is a potential side effect which bares further evaluation in long-term studies to see whether it abates."
poster:River1924
thread:129761
URL: http://www.dr-bob.org/babble/20030125/msgs/137555.html