Posted by Shawn. T. on January 5, 2003, at 23:28:08
In reply to Re: I do believe in norepinephrine (and CRF) » Shawn. T., posted by johnj on January 5, 2003, at 16:48:29
I'm sure that there exist certain susceptibility factors that could make a person more likely to experience antidepressant- induced aggression. I really have no idea about what the best method to counteract the problem might be, but I can give you some suggestions. Serotonin reuptake inhibitors desensitize the 5-HT1A receptors that Buspar exerts its primary mechanism of action at, so combining Buspar with a TCA or duloxetine would likely provide side effects without relief. I wouldn't advise that you try a benzodiazepine because of their side effects (effects on memory, addiction, etc.), but they would probably do the job. You could try alternative medicine; I know that ginseng has been shown to reduce aggressive behavior in mice (do a medline search for verification). Ginseng generally doesn't have any side effects, so it would probably be a good place to start. A standardized extract of Korean or American ginseng would probably be your best bet. One study found that gingko reduced aggression in MAO-A deficient mice, but it's difficult to say how that effect could translate to treating aggression in humans with drug- induced increases in extracellular serotonin and norepinephrine. Gingko may interact with drugs that thin the blood, but it's relatively side effect free otherwise. Another plus from taking ginseng or gingko that you might find with TCA's is a reversal of the potential adverse memory effects from their anticholinergic effects. You mention that you were 'spaced' on Remeron; I didn't have that problem when taking it with Wellbutrin, but I did experience it a bit on Remeron alone. Taking extracts of ginseng and gingko seems to prevent those effects in my case at least. Hope that helps,
Shawn
poster:Shawn. T.
thread:133959
URL: http://www.dr-bob.org/babble/20021230/msgs/134685.html