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Re: What do you mean about EFFEXOR L.Dose?

Posted by Caleb462 on January 2, 2003, at 13:52:54

In reply to Re: What do you mean about EFFEXOR L.Dose?, posted by cybercafe on January 1, 2003, at 15:18:34

> > What do you mean about low dosage of effexor (75mg XR)?
> > Why it is different than other SSRIs?
> > You think it acts differently from celexa, paxil, proxac....etc.
> > Please let me know something more!
> > Thanx
> > BRain
>
> at higher dosages (above 225 mg?) it begins to work on norepenephrine as well...
> it also seems to have dopamine antagonism at lower dosages, but behaves as an agonist at higher dosages
> not too sure about the dopamine thing, though


150 mg is the dose where norepinephrine begins to play a signifigant role, though there is some mild norepinephrine activity at the low doses as well. This could explain the subtle differences between low dose Effexor, and say, Celexa.

It goes SOMETHING like this:

Low doses (37.5 mg to 75 mg): Serotonin Reuptake Inhibitor

Medium doses (150 mg and above): Serotonin Reuptake Inhibitor/Norepinephrine Reuptake Inhibitor

Large doses (Not sure the figures, but my assumption is in the 300-500 mg range): Serotonin Reuptake Inhibitor/Norepinephrine Reuptake Inhibitor/Dopamine Reuptake Inhibitor


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URL: http://www.dr-bob.org/babble/20021230/msgs/134133.html