Posted by SLS on December 29, 2002, at 11:16:29
In reply to Moclobemide (Aurorix) to Prevent Depression, posted by cubbybear on December 29, 2002, at 3:37:29
> Well, unfortunately I had a depressive relapse this week. I had been taking the low dose of 300 mg Aurorix for 3 weeks, and then wham--depression again. But the relapse didn't just come out of the blue: extreme frustrations with my job plus having a close friend terminate our friendship of 7 years proved to be the triggers to get the depression machine running again. . I told my dr. all that had happened and he told me to immediately raise the dose to 450 mg.,Now I'm just praying that this medication--which I've been hoping would be a a viable alternative to all the other stuff out there--will knock out the depression. The mixed reactions I've read on this board about Moclobemide have me worried that it might not work out. Any (positive!) comments from anyone about Aurorix would be appreciated.
Positive:It works for some people and is generally without side effects, even at high dosages. People like it for its lack of sexual side effects.
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Not so positive:
The problem with moclobemide is that most people need higher and higher dosages to maintain an antidepressant effect - often up to 1200mg. Certainly, one should plan to go up to 900mg. 450mg is generally accepted to be the minimum effective dosage of moclobemide.
Moclobemide is a reversible MAO inhibitor. It is probably accurate to say that reversibility equates to reduced efficacy. Moclobemide is generally weaker than the irreversible MAOIs, Parnate, Nardil, and Marplan.
Of course, there are some people who benefit quite a bit from moclobemide. You won't know until you try. I know your aim is to use it as a prophylactic once you have established a remission with Parnate. You are the first person I have heard of to want to use it this way. I doubt anyone can answer your question with certainty. It might be a valid approach. For now, I wouldn't be bashful about going up to 900mg if you are not experiencing severe side-effects.
Why don't you want to take Parnate?
Good luck with moclobemide. It is worth a try.
- Scott
poster:SLS
thread:133624
URL: http://www.dr-bob.org/babble/20021223/msgs/133656.html