Posted by Thygrrr on December 17, 2002, at 17:34:23
In reply to What's the therapeutical difference?, posted by tensor on December 16, 2002, at 4:10:15
Educated guesses from a biologist's son:
Reuptake Inhibition: Impulses last longer, are more intense. On high doses, the reuptake inhibitors will deplete you of dopamin (as cocaine does, for example). Possible connection to Parkinson here. It is generally believed that reuptake inhibitors do have a long-term impact (i.e. depletion potential), though it's not strong enough to be clinically relevant in every case.
Release: Impulses are transmitted faster, earlier, more intensely, may last longer, though metabolism can get screwy ('exhausted' release cells, or falsely transmitted impulses). Since you have only a very limited number of dopaminergic neurons, losing them due to overstress, etc., is very, very bad. Can lead to Parkinson. Taking a neuroprotective agent might be very advisable.
Increase: You just have more? I'd put that in the same category as release; though I'd say that increased production will have less negative 'balance-related' effects; but will certainly increase the aging of the dopaminergic cells. Taking a neuroprotective agent might be very advisable.
poster:Thygrrr
thread:131964
URL: http://www.dr-bob.org/babble/20021217/msgs/132211.html