Posted by BrittPark on December 6, 2002, at 16:05:57
In reply to Re: Clonazepam ... » Willow, posted by sergios_c on December 4, 2002, at 6:08:36
Actually, in general, tolerance to opiates declines quite rapidly with abstinence. That's why there are so many heroin deaths. Somebody gets clean and then falls off the bandwagon and ends up taking too much. Sid Vicious is perhaps the most famous example of this.
You can find out about the seemingly paradoxical efffects of low dose naltrexone or naloxone by doing a MedLine search on Crain and Chen. They are the founders of a company called Pain Therapeutics. If their formulations make it to market and prove to be as non-tolerance inducing as hoped, they will be a great boon to pain-management and perhaps to depression management. (Their is a small body of clinical research that shows that buprenorphine is sometimes effective at treating TRD patients. There are also a small number of Psychiatrists who use opioids in treatment. In general, however, broaching the subject of opiates with your average psychiatrist is likely to get you nothing but dirty looks.)
Britt
poster:BrittPark
thread:130122
URL: http://www.dr-bob.org/babble/20021203/msgs/130792.html