Posted by Anna Laura on November 17, 2002, at 20:26:48
In reply to l-deprenyl plus dexedrine ?, posted by dennison on November 16, 2002, at 14:50:50
> Hi--:) I'm trying regiment of zoloft and dexedrine but the dexedrine seems to lose it effect somewhat when combined with an ssri -has anyone tried adding l-deprenyl at 10mgs a day to dexedrine. I'm aware of the fact that l-deprenyl must be kept at 10mgs a day or it will begin to effect serotonin thus risking the serotonin syndrome. ok thanks !!! :)
from an old post :
Vince,
>
> Memantine, for me at least, is effective for amphetamine tolerance. Whereas before it would poop out ofter about 3 days, leaving me wrung out and irritable, it now gives me a smooth effect (one dosage of 40mg. lasts about 12hours), that I can take every day- giving me energy, concentration, motivation and social confidence.
>
> I've waited to log this post because I was hoping to learn exactly what mechanisms allowed memantine to work this way. But, at this point, at least, I will have to say that it is a bit of a mystery. Presumable, amphetamine induces hyperglutaminergic activity, which incuces the tolerance, which the memantne is able to prevent by limiting glutaminergic activity to within physiologically safe bounds.
>
> Also memantine is seemingly effective for tardive dyskinsia (see patent referred to above). Also effective as a adjunct mood stabilizer to valporate acid (sp?) and possibly lamotrigine.
> It is speculated to be effective for OCD disorders. Also I can't help but wonder if it won't prevent , at least in some , instances, of AD poop out.
>
> BTW: I take, 5mg/day selegiline, 40mg/day adderall, 30mg./day memantine, 4g.day klonopin at night and 50mg./day of amisulpride.
>
> AndrewB
poster:Anna Laura
thread:127937
URL: http://www.dr-bob.org/babble/20021116/msgs/128060.html