Posted by Larry Hoover on November 7, 2002, at 18:36:34
In reply to Re: Opiates = the Devil Amphetamines = Angels? » Larry Hoover, posted by BrittPark on November 6, 2002, at 11:50:24
I started looking at opiates all over again, and I'm finding some recent studies showing bizarre and seemingly contradictory effects.....one substance simultaneously acting as an agonist, inverse agonist and antagonist, in the same signalling system....dimerization of all sorts of receptors... not just opiate/opiate, but also sigma/opiate and alpha-2 adrenergic/opiate.....simultaneous up-regulation of sensitivity with down-regulation of receptor trafficking.....I don't know how on earth one is supposed to make sense of this all.
Maybe opiates *are* the devils work....
Lar
poster:Larry Hoover
thread:126471
URL: http://www.dr-bob.org/babble/20021101/msgs/126880.html