Posted by Halfway on October 28, 2002, at 16:43:05
In reply to Celexa/Provigil/Klonopin, posted by Amberlin on October 28, 2002, at 13:20:44
Lin,
Evidently, Provigil augments most SSRIs nicely...except for Celexa. Check out link below. Among the babblers are some experts on P450 interactions, who can probably explain this better. You may want to consider a different stimulant before giving up on the Celexa. Just a thought...
Jist of article (full link below):
"Statistically significant improvements in energy and concentration as measured by a sub-scale of the Hamilton Depression Scale (HAM-D retardation scale) were seen in patients taking Provigil(r) and various antidepressants including Prozac(r) (fluoxetine HCl), Zoloft(r) (sertraline HCl), or Paxil(r) (paroxetine HCl) but as anticipated, not in patients taking Celexa™, (citalopram HBr), a compound with which Provigil(r) has a known metabolic interaction. Results on the overall Hamilton Depression Scale, which contains elements that are not influenced by fatigue and cognitive function, did not distinguish Provigil(r) from placebo."
http://talkaboutsleep.com/news/Provigil_Depression.htm
poster:Halfway
thread:125550
URL: http://www.dr-bob.org/babble/20021025/msgs/125573.html