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DA blockers and tardive movement disorders

Posted by chad_3 on October 22, 2002, at 19:37:56

In reply to chad 3 Re: Sorry to hear that happened ... , posted by McPac on October 21, 2002, at 23:25:15

Hi -

DA blocker = Dopamine blocker.
All antipsychotics are dopamine blockers. The only other USA drug which blocks dopamine which is not an antipsychotic is "Reglan" (metaclopramide). Reglan is used for nausea and quite notorious for inducing movement disorders - amazing it is still approved for nausea in USA.

Anyway - the antipsychotics are the 'old style" and the "newer style'. Both can induce both tempoary, and permanent ( up to lifelong and sometimes progressive) - movement disorders. The type of movement disorders is staggering - something I learned only because I read up on it after developing a problem.

"Tardive Dyskinesia" is far from the only drug induced disorder - there are about a dozen or more which are clearly definted - although often a combo or mixed forms emerge - making clear dx difficult.

Zoloft cannot *cause* permanent movement disorder. It *can* cause an existing problem to "appear" - which will generally reverse on discontinuation.

This is in opposite to a DA blocker - which when started may not show any problem - and on discontinuation - the caused movement disorder *appears* - which can then again be *masked* by again taking the DA blocker. Continuing the DA blocker will typically make the problem worse and worse as time goes on. Higher doses may be required simply to *mask* the movements. Discontinuation of the DA blocker may become impossible - even early on in some cases.

Chad
http://www.socialfear.com/


> What is a DA blocker?
> Also, what drugs are DA blockers?
> Finally, can Zoloft make movement disorders worse?
> Thanks!


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