Posted by Shawn. T. on October 21, 2002, at 22:31:29
In reply to Re: Remeron vs. Paxil » Essence, posted by LyndaK on October 21, 2002, at 12:47:01
>>Any insights into why you DIDN'T gain weight?
One possible explanation for weight gain from antipsychotics/Remeron is that 5-HT2C antagonism is primarily responsible for the effect.
Lancet 2002 Jun 15;359(9323):2086-7 Related Articles, Links
Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.Reynolds GP, Zhang ZJ, Zhang XB.
Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK. g.p.reynolds@sheffield.ac.uk
A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with schizophrenia. We noted significantly less weight gain in patients with the -759T variant allele (p=0.0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0.002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain.
Shawn
poster:Shawn. T.
thread:124409
URL: http://www.dr-bob.org/babble/20021019/msgs/124605.html