Posted by Rick on October 15, 2002, at 23:12:01
In reply to American Journal of Psychiatry: Paxil not an SSRI, posted by Shawn. T. on October 15, 2002, at 16:18:07
Very interesting! I understand that none of the SSRI's are really completely "selective" (although the Lexa's are close), but it's surprising to see how much of an adrenergic impact Paxil has.
But re the conclusion that noradrenaline reuptake inhibition underlies the withdrawal difficulties... aren't there other NRI's (some TCA's, reboxetine) that *aren't* known for withdrawal distress?
Rick
> I really can't express how much of a shame this situation is. I believe that most people on this board would accept that the withdrawal effects of the SSRI+noradrenaline reuptake inhibitor Effexor are more severe than those of the SSRI's. An obvious conclusion is that the effects on noradrenaline cause the problem. Based on this logic, Paxil is more addictive than the other SSRI's. In fact, Paxil is not a selective serotonin reuptake inhibitor according to a recent article in the American Journal of Psychiatry. In vivo, Paxil inhibits noradrenaline reuptake by approximately 27%. So the next time you hear that the "selective" serotonin reuptake inhibitor Paxil isn't addictive, you should thank the FDA for allowing such lies to be spread.
>
> http://ajp.psychiatryonline.org/cgi/content/abstract/159/10/1702
>
> Shawn
poster:Rick
thread:123399
URL: http://www.dr-bob.org/babble/20021012/msgs/123843.html