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Re: potential Breakthrough in anxiety trtmt, contacts

Posted by Shawn. T. on October 15, 2002, at 16:03:08

In reply to potential Breakthrough in anxiety trtmt, contacts, posted by temoigneur on October 15, 2002, at 14:49:34

A selective PKC epsilon inhibitor does not yet exist. You should realize that no one knows how a drug like that would affect humans, especially with long-term use. If it does turn out to work well, it will still be many years before you see a PKC epsilon inhibitor on the market. Drugs that are closer on the horizon are cholecystokinin B (CCK2) receptor antagonists for panic attacks and anxiety. Some of these drugs are in clinical trials and are based on genetic data rather than knockout mice with a supersensitivity to alcohol. I know that Glaxo is developing some drugs like this, and I'm sure that other drug companies probably are as well. The link is to a comprehensive review of CCK.

http://pharmrev.aspetjournals.org/cgi/content/full/51/4/745?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1031537213010_681&stored_search=&FIRSTINDEX=10&minscore=50&journalcode=pharmrev#SEC7_2_2


Shawn


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poster:Shawn. T. thread:123673
URL: http://www.dr-bob.org/babble/20021012/msgs/123793.html