Posted by JLM on October 1, 2002, at 5:51:57
In reply to Re: s-citalopram and r-citalopram, posted by JLM on October 1, 2002, at 4:48:16
> > There is a lot of evidence on this sort of thing at http://www.cipralex.ch/f/poster.html
> >
> > The study
> > http://www.cipralex.ch/pdf/poster/sobp_500.pdf
> > in particular demonstrates that s-citalopram is almost entirely responsible for the SSRI activity of citalopram.
> >
> > In terms of evidence for r-citalopram causing side-effects - there just isn't any. An interesting thing to look at is the bit at the botttom of
> > http://www.cipralex.ch/pdf/poster/ifmad_01.pdf
> > where it says 'Escitalopram has demonstrated a lack of affinity for a very large number of receptors and binding sites - measured as citalopram'. This is followed by a list of over 50 receptors. What this shows is that this lack of activity must also be true of r-citalopram, because the results are for s- and r-citalopram combined.
> >
> > I keep on asking for any evidence that r-citalopram causes side-effects and no-one can come up with anything - but it gets repeated as a known fact. What can you do?
> >
> >
> > > > Where is the evidence that the s-isomer is the one that causes the so called AD effect, and that the r-isomer causes SE's? I have yet to see anyone present that here. Forrest certainly cannot back that claim up with hard data.
> > >
> > >
> >
> >
>
> Dr. Dave thanks for that info, I will take a look at that. Very useful.
>
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Dr. Dave, I was doing some surfing tonight and came across some studies/info about the non-racemic version of Fluoxetine, r-fluoxetine. Apparently before research on the compound was stopped due to the danger of prolonged QT intervals, they were making the same claim that Forrest is making about s-citalopram, namely less side effects from the non-racemic mixture.Is this going to be the new trend? Was there any actual evidence that r-fluoxetine caused less side effects? It makes one wonder, how many other stereoisomer drugs we are going to see with claims off less SE's, especially in the area of psychiatric drugs.
poster:JLM
thread:121478
URL: http://www.dr-bob.org/babble/20020930/msgs/121776.html