Posted by pharmrep on September 27, 2002, at 23:58:41
In reply to Re: Lexapro side-effects/dosage, posted by yeltom on September 27, 2002, at 22:18:05
*** you are right...Dr Dave wont agree with this point...Celexa is a racemic mixture with "mirror" halves..r-cit. and s-cit (50/50 mix) the r-cit does not contribute towards treating depressive symptoms at all (see sanchez study) and actually inhibits the s-cit (lexapro) from its full potential. it wasnt expected at first...but 10mg is at least as efficacious as 40mg of celexa.
But your conclusion is based on the idea that 10 mg. of Lexapro is equivalent to 20 mg. of Celexa, whereas the company claims that it's equivalent to 40 mg. Am I wrong? I am curious, however, why isolating one of the isomers would make it 4 times stronger. I assumed that the two isomers in celexa were present in a ratio of 1:1, in which case you'd assume (assuming that the less active isomer is not active at all) that the isomer would be twice as strong, not 4 times as strong. Unless the non-active component actually INHIBITS the active component. Or perhaps the assumption that they are present in a ratio of 1:1 is wrong.
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poster:pharmrep
thread:109458
URL: http://www.dr-bob.org/babble/20020922/msgs/121337.html