Posted by Dave001 on September 5, 2002, at 18:29:07
In reply to Re: About 20 to 60 mg/day, but ..., posted by jsarirose on August 31, 2002, at 14:05:09
Something I've wondered, but have not taken the time to research, is the degree of MAO inhibition achieved at varying dosages. I'd love to see a graph of that. I find it odd that the dosing schedule can make such a big difference to people in terms of side-effects, given the affinity and irreversibility of binding to MAO. Is the enzyme synthesized so fast that the effect can begin to wear off in a matter of hours?
Also, while dietary and drug interactions are obviously something that ought to be taken very seriously, I'm wondering why hypertensive crises tend to occur without a nearly 100% inhibition of MAO; or is it that such a high degree of inhibition is necessary for therapeutic effectiveness? For instance, suppose one has a level of 70% MAO inhibition; does that not leave enough MAO to metabolize the paltry amounts of tyramine found in the restricted foods??
Dave
poster:Dave001
thread:118185
URL: http://www.dr-bob.org/babble/20020829/msgs/118940.html