Posted by Maximus on August 7, 2002, at 20:46:50
In reply to Apples and oranges, posted by Squiggles on August 7, 2002, at 15:59:15
> As for conversion of Lamactal to Lithium,
> since one is a GABBA drug and the other
> an inositol drug - yeah apples and oranges,
> unless you compare them phenomenologically.I'm sorry but i don't know what you are talking about. However, both molecules have an extremely complexed mechanism of action. (Shortly), Lamictal is an inhibiter of the "glutamate" release. Even if Lithium has a slight enhancing action on GABA, its main action is on "glutamate" too. Both Lamictal and Lithium are associated with a reduction of NMDA receptor-mediated calcium-sodium influx.
They have both their weakness and their forces. Taking the two is taking the best of the both worlds (even if they aren't totally different), as you can see.
http://www.apa.org/monitor/sep98/lith.html
http://www.pslgroup.com/dg/8CF9A.htm
http://www.sciencenews.org/sn_arc98/3_14_98/fob3.htm
http://www.mddaboston.org/lect032200.htmlhttp://www.glaxowellcome.com.sa/Products/CNS.htm
http://www.nmhct.nhs.uk/pharmacy/epi2.htmAnd so on...
Hope that helps!
poster:Maximus
thread:115571
URL: http://www.dr-bob.org/babble/20020807/msgs/115598.html