Posted by Shawn. T. on July 29, 2002, at 2:13:54
In reply to Bipolar II's and AD's, posted by johnj on July 28, 2002, at 11:41:05
Remeron makes you drowsy, and Wellbutrin makes you have insomnia. Remeron makes you gain weight, and Wellbutrin typically makes you lose it. I have bipolar II, and the combination works well for me. I seem to be the only person in the world that thinks having a ton of noradrenaline flowing through you isn't such a great thing, so I really don't recommend over 15mg of Remeron to anyone. Believe it or not, you will experience side effects if you take a large dose (I may be one of the few people around here who believes this to be true). Wellbutrin's noradrenaline reuptake mechanism is interesting because it actually decreases the firing rate of noradrenaline neurons. This is due to an increased activation of inhibitory somatodendritic alpha-2-adrenoceptors. Remeron blocks those receptors. So combining too much Remeron with Wellbutrin is a bad idea, but combining just a little (7.5-15mg/day) with it will do nicely. Individual reports have cited that this is an excellent combination for treatment resistant depression, and it should not switch you into a manic episode.
Throw in some fish oils and skip out on the mood regulators (Remeron has a certain level of mood regulation on its own). Whatever you do, do not under any circumstances take an SSRI.Shawn
poster:Shawn. T.
thread:114019
URL: http://www.dr-bob.org/babble/20020725/msgs/114122.html