Information overload on depression, bipolar, etc.

Posted by Shawn. T. on July 18, 2002, at 23:24:08

In reply to Inisotol linked to bipolar disorder, posted by Shawn. T. on July 18, 2002, at 20:44:04

I'm not going to answer another question about SSRI's or tricyclics; these drugs are anything but selective. Don't take St. John's Wort. Don't take MAOI's. Don't take 5-HTP (I'm reversing myself on this). Don't take trycyclic antidepressants. I fear that I might have to give up my iron grip on Remeron someday (although I'm sure 7.5mg/day is helping me). Benzo's are just as bad as barbituates. If you can't go to sleep, try melatonin instead of something that is going to kill your memory. These drugs are anything but selective, as in NOT SELECTIVE! I'm fed up with the health care system in general. Who is in charge here?
What do we need to effectively treat depression? A drug with 5-HT2a agonism mixed with 5-HT2c agonism a la meta-chlorophenylpiperazine (mCPP)
perhaps. We could add on 5-HT1a antagonism to prevent excess hormone excretion. Perhaps a 5-HT2a/c agonist in rotation with a 5-HT2a/c antagonist and 5-HT1a agonist? My reasoning concerning the previous statement revolves around the fact that the receptors will adjust their sensitivity in response to the drugs (they will not up or down regulate). I don't expect everyone to ingest eighteen grams of inisotol a day! There has to be a way around antidepressant poop-out (loss in efficacy). Perhaps my idea would help?
There's a massive amount of information about bipolar disorder contained in the links given. I now realize why drugs like Zyprexa (I'm not endorsing that drug) work for bipolars. 5-HT2c antagonism is the key for bipolars. Perhaps 5-HT2a antagonism is important as well.
I am definitely starting to notice a pattern. Depression & anxiety are related to a genetically determined excess of 5-HT2a and 5-HT2c receptors.
SSRI's and the like make these receptors more sensitive (albeit in a crude fashion). Some people with depression or anxiety symptoms have an uncommonly small number of 5-HT2a and 5-HT2c receptors. People with bipolar disorder probably have too few 5-HT2c (5-HT2a?) receptors. They cycle because of changes in the sensitivity of their 5-HT2c receptors. I would guess that people with ADHD have too few 5-HT2c receptors as well (but not as few as seen in bipolar perhaps). Once again, I am only speculating on ADHD (I will read up on that sometime).
"Biochemical functions defined for phosphatidylinositol in biological membranes include the regulation of cellular responses to external stimuli and/or nerve transmission as well as the mediation of enzyme activity through interactions with various specific proteins."
It's all coming together; the body is amazingly complex. I quoted that because it shows the link between inisotol and enzyme activity.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9855568&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
These are some amazing times that we live in.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9203091&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
"Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder."
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11853115&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Adenylate cyclase, inisotol and serotonin.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=8021439&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247

Depression linked to Ins(1,4,5)P3 receptors.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9694526&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
5-HT receptors are *not* homogeneous!
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=24213838
On the "genetic origin" of depression, etc.
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=25005355
Read the next two together.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=1350770&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
http://www4.infotrieve.com/newmedline/detail.asp?NameID=1847229&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Some information about alpha-1-adrenergic actions.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=1666557&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inisotol and OCD.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11267629&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inositol and bulimia.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11262515&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247

Inositol v. Fluvox for PD.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11386498&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
I think I'll take a stretch break.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=1317961&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
How to discriminate for the placebo effect.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=7622343&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Higher levels of monoamines probably unnecessary to treat depression, others.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=10647093&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Please don't take too much calcium.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=8143920&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Take calcium supplements if you're afraid that your transporters might be "broken."
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11245676&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Yes, calcium is very important.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11196578&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
More on calcium.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11086997&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
A bit on calcium and inisotol.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9874373&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
How to tell if you need inisotol/lithium.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=10907738&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inisotol in humans.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9169302&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inisotol comparable to imipramine.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=7675981&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
More on inisotol in animals.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11172878&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inisotol and lithium, seizures, anxiety.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11122916&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
More on lithium.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9674936&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Beyond lithium for bipolars.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=10445037&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
More on lithium and its alternatives.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=8836446&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Myo-inisitol for depression, OCD, PD.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9784079&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
5-HT2C agonism and depression.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9694950&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Inisotol and OCD.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=8780431&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
What exactly is that fish oil doing?
http://www4.infotrieve.com/newmedline/detail.asp?NameID=8381824&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
I've really got to start reading more about cancer; this is hard to follow but important.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9381980&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
More on adrenergic processes.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=2551395&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
I still don't like tricyclics.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=2138225&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
Sort of dull reading material.
http://www4.infotrieve.com/newmedline/detail.asp?NameID=9203370&loggedusing=M&Session=&SearchQuery=depression+AND+inositol&count=247
What a nice site, really.
http://www.biopsychiatry.com/5ht2arev.htm
This one is very useful as well.
http://www.pharmcentral.com/
This one too.
http://www-np.unimaas.nl/PsyPharm/postersBAP/posterwim.html

Thread

Inisotol linked to bipolar disorder Shawn. T. 7/18/02
Re: Inisotol linked to bipolar disorderShawn jaby 7/18/02
Information overload on depression, bipolar, etc. Shawn. T. 7/18/02
Re: Inisotol linked to bipolar disorderShawn Shawn. T. 7/19/02
Re: Information overload on depression, bipolar, etc. » Shawn. T. turalizz 7/19/02
general info on inositol katekite 7/19/02
Re: general info on inositol » katekite Shawn. T. 7/19/02
Re: Information overload on depression, bipolar, etc. » turalizz Shawn. T. 7/19/02
Ditch your lithium Shawn. T. 7/19/02
Re: Information overload on depression, bipolar, etc. » Shawn. T. turalizz 7/20/02
Re: Information overload on depression, bipolar, etc. » turalizz Shawn. T. 7/20/02
Re: Information overload on depression, bipolar, etc. cybercafe 7/21/02
Clarifications » cybercafe Shawn. T. 7/21/02

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poster:Shawn. T. thread:112842
URL: http://www.dr-bob.org/babble/20020718/msgs/112856.html