Posted by hawkeye on July 18, 2002, at 6:29:37
In reply to Re: enhancing and decreasing the same neurotransmitter, posted by hawkeye on July 18, 2002, at 6:04:03
Last paragraph in quote in above post dhpould read:
"In an attempt to resolve the paradox, it has been suggested that when neurons fire at an abnormaiiy high rate for about a three-week period, their celi membranes "depolarize." Depolarization refers to a reduction in the voìtage differential between the celi membrane and the cytopiasm within the neuron, a condition that biocks the ability of a neuron to fire and to release its transmitter. It has been reported in a recent study that the capacity of chronic administration of different antipsychotic drugs to produce depolarization block of dopamine neurons was reiated to their antipsychotic efflcacy in humans. While the depolarization block phenomenon may prove useful for screening new antipsychotic drugs, its significance for the dopamine theory of schizophrenia is not at all clear. The principal researchers working on the depolarization effects of antipsychotic drugs believe that there is no reason to think that depolarization represents a return to the normal state of the dopamine system, and they conclude that there is probably nothing at all wrong with the dopamine system in schizophrenics."
poster:hawkeye
thread:112626
URL: http://www.dr-bob.org/babble/20020718/msgs/112749.html