Posted by Sparkboy on June 27, 2002, at 13:56:29
In reply to Im on the MAOI Parnate, posted by LostBoyinNC1 on June 25, 2002, at 23:44:13
Eric
Glad you're still around. Give the Parnate a good 3-4 weeks. I had insomnia (3 hours sleep) and anxiety attacks for the first 10 days, then calm and warmth--suddenly, like flipping a switch.
I've found that the various phases of atypical depression can be shifted solely by manipulating hours of sleep. I believe atypical depression mimics bipolar conditions and gets mistaken for them.
Don't know if you remember, but I tried Stablon (tianeptine), serotonin re-uptake enhancer, in Summer 2000. It brought irritability and oversleeping that was associated with my winter phase. This leads me to believe that atypical depression is some derangement of serotonin receptors, not helped by SSRIs or re-uptake inhibitors.
A new drug called Ariza (gepirone) from Organon, was due to be released this year, but is the latest victim of FDA foot-dragging. Related to buspirone, it hits more powerfully on 5-HT 1A, without the mild blocking on D2. Nearly half of atypicals responded to it in one study (poss. unpublished data). Interest in this drug for atypicals has been bouncing around almost as long as this drug has been in research (1985!).
Good luck with the Parnate, Eric. Glad you haven't given up. It's hard.
--John
poster:Sparkboy
thread:110769
URL: http://www.dr-bob.org/babble/20020617/msgs/110933.html