Posted by JohnX2 on June 13, 2002, at 23:35:46
In reply to mood stabilizers for lack of response to ad's?, posted by jonh kimble on June 11, 2002, at 18:11:03
> as some know, i have dysthymia, social anxiety, chronic fatigue, and that sort of thing and i have not responded to any of 12 ad's, and i had a reasonible response to dexedrine but only now and then. people here have told me about mood stabilizers but i thought that these were only for bi polar. im begining to get more interested in the idea. for example, a drug i read about called memantine apperently helps with stimulant poop out and crack addicts who took it reported a much greater effect when they smoked crack (this was in a study by the way)
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> memantine is an nmda antagonist, and i understand some mood stabilizers are too. but i read the side effect profile for some and side effects included sedation and weight loss. i already have a terrible time with these. also i heard that some decrease levels of tyrosine hydroxylase, which means less DA/NE and these seem to be low in me already.
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> one thing i wanted to add is that alcohol really makes me awake, and when i smoke, i get a nicotine buzz every time. normally when i smoke i only feel nicotine about 6 times a day. dont know if this means anything.
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> anyway, id appreciate any more info and experiences. thanks
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> jonJust a thought...
You may consider either Lithium or Lamictal.
Both medicines modulate glutamate activity (as does
memantine, but each in its own way).Lamictal is an antiseizure medicine but has antidepressant
properties (not fully understood). It has a low side effect
profile and you can augment this with another AD.Lithium has been used for quite a while as an augmentation
to standard ADs for treatment resistanct unipolar
depression.Both medicines can treat bi or uni-polar depressions.
Regarding tyrosine-hydroxylase, almost every norepinephrine
reuptake inhibitor AD and MAO inhibitors decrease
tyrosine-hydroxylase as part of the training process.
I've only seen one small abstract to the contrary and this
was with selegiline in parkinson's patients.John
poster:JohnX2
thread:109514
URL: http://www.dr-bob.org/babble/20020609/msgs/109763.html