What happened to the new generation anxiolytics?

Posted by 3 Beer Effect on June 4, 2002, at 0:03:03

I thought a whole bunch of new generation anxiolytics were in the pipeline/ going to be approved by the FDA? Where are they?
1. Partial Benzodiazpine Agonists?
When are the partial benzodiazpine agonists such as alpidem, abecarnil, bretazenil, or others going to be released, or if not what happened to them?
2. New Serotonin 5HT-1A Agonists?
Where are the new Serotonin 5HT1-A agonists that are supposed to replace the largely dissapointing med Buspar?- such as Gepirone ER, Tandospirone, Flesinoxan?
(Found this written year 2000 (2 yrs ago)- "Gepirone ER, a chemical cousin of Buspar is continuing in clinical development in the United States & Tandospirone in Japan."
"Ipsaspirone, Sunepitron, Transdermal Buspar & others have been dropped from clinical development, although there may be some continuting interest in Flesinoxan or others."
3. Dual Serotonin & Dopamine Reuputake Inhibitors such as Minaprine & Bazinaprine?
Also written in year 2000 "Dual reuptake blocker of both serotonin & dopamine are in clinical testing. Although the SSRI Zoloft has some dopamine reuputake inhibition as well as more potent serotonin reuputake inhibition, Minaprine & Bazinaprine have more potent dopamine actions & are thus dual serotonin/dopamine agonists."
3 Beers...........
Source of quotes, "Stahl, Stephen M., Essential Psychopharmacology of Depression and Bipolar Disorder (2000)".

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What happened to the new generation anxiolytics? 3 Beer Effect 6/4/02
The micro-brew start-ups are struggling (nm) JohnX2 6/4/02
Flesinoxan was dropped by Solvay (nm) JohnX2 6/4/02
Re: What happened to the new generation anxiolytics? » 3 Beer Effect Sparkboy 6/5/02
Re: gepirone jrbecker 8/21/02

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