Posted by fachad on June 1, 2002, at 15:30:12
In reply to Re: Trimipramine for Sleep » fachad, posted by katekite on May 31, 2002, at 21:34:11
Were you put on benzos for sleep or anxiety or both? I've heard that for anxiety, benzos are really the best treatment - much better than SSRIs or other alternatives.
For sleep, from an objective standpoint (PSG and EEG), trimipramine is the best med period. I experience better sleep subjectively also, but that will vary from person to person.
The dopamine antagonism of trimpramine is really minimal - much less than the weakest APs. It only looks significant when compared to other ADs, which have little to no DA antagonism.
As far as coding ability, or general cognitive ability, my experience is that trimipramine is far less of problem than Ativan.
Ativan hits me pretty hard the whole next day, both in terms of cognitive impairment and in terms of making me feel a little melancholy.
The trimipramine grogginess dissipates much quicker for me than the Ativan lethargy and melancholy.
Just so you know, my Ativan doses were 1 mg or 2 mg and my trimipramne doses are approx 12.5 mg or 25 mg.
To get 12.5 mg I dump the powder from a 25 mg capsule into a tall glass of water, stir, then drink half the glass. 25mg is the smallest capsule they make, and 12.5 mg does the job for me with less residual effects than 25 mg.
I considered clonadine, but it can cause depression and it can cause rebound high blood pressure when it wears off in the morning. I don't want to introduce any new problems, I already have my lifetime allotment...
> Thanks fachad... I am really interested to hear further info on this and about other alternatives to benzos.... I've now been on klonopin for 9 months and it has really screwed up my sleep. But... try to get off and have rebound insomnia.
>
> The dopamine antagonism has me concerned though, esp residual coding probs next am, etc as I need all my dopamine during the day.
>
> have also been looking at clonidine, used in little kids with ADD to make them sleep, wonder if any adults use it.
>
> kate
poster:fachad
thread:107701
URL: http://www.dr-bob.org/babble/20020525/msgs/108314.html