Posted by JonW on May 22, 2002, at 20:56:48
In reply to Re: concerta - prescription problem... » Ritch, posted by krazy kat on May 22, 2002, at 14:47:39
Hi all,
In the study I've pasted below it says that both dextroamphetamine and modafinil were superior to placebo, but does anyone know more about this study? Were the two meds comparable or was one superior to another?
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Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults.Taylor FB, Russo J.
Rainier Associates, Tacoma, Washington 98467, USA. taylor2@earthlink.net
Our objective was to compare the efficacy of the new wake-promoting drug modafinil to that of dextroamphetamine for the treatment of attention deficit hyperactivity disorder (ADHD) in adults. Twenty-two adults who met DSM-IV criteria for ADHD participated in a randomized, double-blind, placebo-controlled, three-phase crossover study comparing placebo, modafinil, and dextroamphetamine for the treatment of ADHD. The twice-daily study medications were titrated to doses of optimum efficacy over 4-7 days and then held constant during the rest of each 2-week treatment phase. Measures of improvement included the DSM-IV ADHD Behavior Checklist for Adults, the Controlled Oral Word Association Test (COWAT, using the letters C, F, and L version), Stroop, and Digit Span (Wechsler Adult Intelligence Scale version). For the 21 (96%) completers, the mean (+/- SD) optimum doses of modafinil and dextroamphetamine were 206.8 mg/day +/- 84.9 and 21.8 mg/day +/- 8.9, respectively. Scores on the DSM-IV ADHD Checklist (p < 0.001) were significantly improved over the placebo condition following treatment with both active medications. Performance on the COWAT (p < 0.05) reached trend levels of significance. Both medications were generally well tolerated. This preliminary study suggests that modafinil may be a viable alternative to conventional stimulants for the treatment of adults with ADHD.
Publication Types:
Clinical Trial
Randomized Controlled TrialPMID: 11191692 [PubMed - indexed for MEDLINE]
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poster:JonW
thread:104737
URL: http://www.dr-bob.org/babble/20020517/msgs/107350.html