Re: Acamprosate where? » Anna P.

Posted by JohnX2 on May 20, 2002, at 1:36:40

In reply to Re: Acamprosate where?, posted by Anna P. on May 17, 2002, at 0:52:46

> Do you know in which country in Europe, Acamprosate is available?
> I wonder if it could work as a mood stabiliser, just like Naltrexone has worked for me.
>
> Thanks,
>
> Anna P.
Hi Anna,
I know it is available in England. I'm not sure where else.
The mode of action of Acamprosate is quite different from
Naltrexone. Its definately not an apples-to-apples comparison.
There is some clinical interest in Acamprosate as a mood stabilizer
for treatment resistant bipolar (I saw an open study).
Naltrexone antagonizes (blocks) opioid receptors.
Acamprosate has 2 modes of action. It enhaces the release
at Gaba(b) receptors and it also weakly inhibits NMDA (excitatory)
transmission.
Take Care,
John

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Re: Acamprosate where? » Anna P. JohnX2 5/20/02
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