Posted by 3 Beer Effect on May 12, 2002, at 23:02:54
In reply to is dexedrin and deprenyl safe?, posted by jonh kimble on May 12, 2002, at 17:42:51
This is a potentially deadly drug interaction!
Read the PDR US Prescribing info for Adderall, Dexedrine, or Dextrostat. It says deaths & severe hypertensive crises have been attributed to that particular combination of an amphetamine & the mao-b inhibitior l-deprenyl/selegeline.
I wouldn't bet my life on a published, known dangerous drug interaction, it's not worth it.Perhaps you should either take breaks from the Dexedrine once in awhile to prevent tolerance as pointed out below, or switch stimulant medications once in awhile to Adderall or Desoxyn or even Focalin/Concerta.
If the dex poops out, stop taking it on the weekends, and once in awhile take a "stimulant holiday" for 7 days and any tolerance to dexedrine dissapears. Also, taking the amino acid l-tyrosine 500 -1500 mg per day may prevent the onset of tolerance. It seems to work well for me, I have had good success with the "Twinlab" brand of l-tyrosine. In experiments l-tyrosine supplementation tended to work well & increased the subjective effects of amphetamine if taken on an empty stomach 5 hours before your first dexedrine dose. Vitamin B6, folic acid, and C are necessary for your body to metablolize the l-tyrosine, I wouldn't overdo it, you probably only need about the 100% RDA of those three vitamins.
Hope you heed this warning- you can probably find case reports of deaths from the combination of (Dexedrine) dextroamphetamine & Selegeline (l-deprenyl) on PUBmed/Medline if your still not convinced.
3 Beers
poster:3 Beer Effect
thread:106127
URL: http://www.dr-bob.org/babble/20020510/msgs/106151.html